人物名， 著名人物为山东大学教授，博士，山东大学长江学者特聘教授，博士生导师，组合化学研究所所长。1982年1月毕业于山东大学化学系，获学士学位。1986年赴美国哥伦比亚大学化学系学习，师从著名生物有机化学家Koji Naknish教授，并于1990年获博士学位。 1990年至1993年先后师从英国剑桥大学/生理学研究所著名教授Peter A. McNaughton和美国休斯顿德克萨斯微生物和分子基因所世界著名教授John L. Spudich进行博士后研究工作。另有辽宁石油化工大学职业技术学院讲师

山东大学长江学者特聘教授(科研简介 研究方向 研究领域和兴趣 主要论著)

辽宁石油化工大学职业技术学院讲师(人物简介 教学情况 公开出版专著 公开发行的刊物上发表的教学研究论文 获得的教学表彰/奖励)

山东大学长江学者特聘教授

科研简介

1993年至1999年受聘于位于新泽西的Novartis Biomedical Research Institute。他负责创建的研究团队是美国最先投入组合化学研究的团队之一，最先建立了组合化学中应用于固相高通量合成技术中的分析和检测方法及反应动力学研究，推动了固相合成和组合化学的发展。

据不完全统计，闫兵博士在1996年发表在Journal of Organic Chemistry 上该领域内的首创性论文被144次引用，他在该领域发表的7篇主要论文被引用次数迄今为止已超过625次。其研究成果很快得到了国际学术界的公认和好评，并被美国化学学会ACS 出版发行的Chemical Engineering News （April 6, 1998）报道。

1998年，他和其他学术带头人在Anthony Czarnic 博士的带领下为美国化学学会创刊发行了Journal of Combinatorial Chemistry （JCC），并担任两届编委至今。现任该杂志副主编。

1999年至2005年，他受聘于美国Discovery Partners International和Bristal-Myers Squibb，在组合化学中的合成、纯化和质量控制及用于早期药物开发的高通量筛选领域从事研究工作。

2001年当选为Sigma Xi成员，并于2002及2004年应邀在匹兹堡会议上组织和主持了两次国际专题研讨会：PittCon 2002 和 PittCon 2004。

于2007年在FACSS会议上主持国际专题会议。

闫兵博士组织并主持国际学术会议6次，17次应邀在国际学术会议上作大会报告或特约报告，在分析化学和组合化学分析领域撰写专著4部，主编著作4部，并发表了11部书章节或综述文 章，在Nature, Proc.Natl.Acad.Sci.USA, Curr.Opin.Chem.Biol., Acc. Chem.Res., Biochemistry, Biophys. J., Nano Lett., J.Med.Chem., Anal.Chem., J. Biol.Chem.和J.Comb.Chem.等杂志上发表论文74篇，发表论文被他人引用超过1530次。

研究方向

主要从事组合化学、纳米医药及纳米毒理学和新型抗癌药物研发等领域的研究。他负责创建的研究团队是国际上最先投入组合化学研究的团队之一，最先提出了大量组合化学中应用于固相高通量合成技术中的分析和提纯方法，推动了固相合成和组合化学的全面发展。据不完全统计，1996年他发表在Journal of Organic Chemistry上该领域内的首创性论文被130次引用，他的7篇主要论文被引用次数迄今为止已超过500次。其在组合化学中的合成、纯化和质量控制及用于早期药物开发的高通量筛选领域的研究达到世界领先地位，许多由他及其助手开发出的化合物被用于药物的临床实验。主持国家自然科学技基金委项目 “应用组合化学和高通量筛选技术开发新型特效饮用水除砷剂”（项目批准号 20577029），2006。在分析化学和组合化学分析领域撰写专著4部，参与另外11部书章节或综述文章的编写工作，在高影响因子SCI杂志上发表论文70余篇，发表论文被他人正面引用超过1280次。

研究领域和兴趣

We use modern discovery tools such as combinatorial chemistry, high-throughput screening, computation and biological techniques to study some fundamental problems and processes in biology and medicine. Our research directions are two fold: the first is to modulate biological specificities of nanomaterials by controlling their surface chemistry to study their surface structure-activity and structure-toxicity relationships and discover biocompatible and cancer targeting nanomedicine and nanodiagnostics; the second is to develop anti-cancer chemical agents that target drug resistant cancers or molecular probes to understand biological processes. The drug development is a very long process. Our focus is to discover and optimize lead compounds, study the mechanism of action, and complete preclinical research for top candidates. We also develop various drug discovery and analytical chemistry technologies to assist our research goals and train graduate students (M.S. and Ph.D.) and postdoctoral fellows.

主要论著

1. Gao NN, Zhang Q, Mu QX, Bai YH, Li LW, Zhou HY, Butch E, Powell T, Snyder SE, Jiang GB, Yan B.* Steering Carbon Nanotubes to Scavenger Receptor Recognition by Nanotube Surface Chemistry Modification Partially Alleviates NF¦ÊB Activation and Reduces Its Immunotoxicity. ACS Nano, Web Publication Date: May 19, 2011.

2. Li LW, Zhang Q, Liu AF, Li, XE, Zhou HY, Liu Y, Yan B.* Proteome Interrogation Using Nanoprobes to Identify Targets of a Cancer-killing Molecule. J Am Chem Soc 2011, 133(18), 6886-6889.

3. Zhou HY, Jiao PF, Yang L, Li X, Yan B.* Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array. J Am Chem Soc 2011, 133(4), 680-682.

4. Yu C, Zhang J, Chen L*, Li J, Liu P, Wang W, Yan B.* ¡°Off-On¡± Based Fluorescent Chemosensor for Cu2+ in Aqueous Media and Living Cells. Talanta 2011, in press.

5. Liu YJ, Zhang B, Yan B.* Enabling Anticancer Therapeutics by Nanoparticle Carriers: The Delivery of Paclitaxel. Int J Mol Sci 2011, in press.

6. Andersson AK, Miller DW, Lynch J, Lemoff AS, Cai Z, Pounds SB, Radtke I, Yan B, Schuetz JD, Rubnitz JE, Ribeiro RC, Raimondi SC, Zhang J, Mullighan CG, Shurtleff SA, Schulman BA, Downing JR. IDH1 and IDH2 Mutations in Pediatric Acute Leukemia. Leukemia, Web Publication Date: June 7, 2011.

7. Hurdle JG, Heathcott AE, Yang L, Yan B, Lee RE. Reutericyclin and Related Analogues Kill Stationary Phase Clostridium Difficile at Achievable Colonic Concentrations. J Antimicrob Chemother Web Publication Date: May 31, 2011.

8. Tekobo S, Richter AG, Dergunov SA, Pingali SV, Urban VS, Yan B, Pinkhassik E. Synthesis, Characterization, and Controlled Aggregation of Biotemplated Organic Nanodisks. J Nanoparticle Research, Web Publication Date: May 11, 2011.

9. Zhou QF, Dergunov SA, Zhang Y, Li X, Mu QX, Zhang Q, Jiang GB, Pinkhassik F, Yan B.* Safety profile and cellular uptake of biotemplated nanocapsules with nanometer-thin walls. Nanoscale, Web Publication Date: April 20, 2011.

10. Wu L and Yan B.* Discovery of Small Molecules that Target Autophagy for Cancer Treatment. Current Medicinal Chemistry 2011, 18(12), 1866-1873.

11. Yan B. Impacts of Nanotechnology on Medicinal Chemistry and Drug Discovery. Current Medicinal Chemistry 2011, 18(14), 2044.

12. Jiao P, Zhou H, Chen L, Yan B.* Cancer-Targeting Multifunctionalized Gold Nanoparticles in Imaging and Therapy. Current Medicinal Chemistry 2011, 18(14), 2086-2102.

13. Yan B, Editorial: Nano-Combinatorial Chemistry and Associated Technologies, Combinatorial Chemistry & High Throughput Screening 2011, 14(3), 146.

14. Zhang W, Penmatsar H, Ren A, Punchihewa C, Lemoff A, Yan B, Fujii N and Naren AP. Functional Regulation of CFTR-Containing Macromolecular Complexes: A Small-Molecule Inhibitor Approach. Biochemical Journal 2011, 435, 451¨C462 (Highlighted by Commentary "Targeting the regulation of CFTR channels" by Paul DWE and Christine EB, Biochem J 2011, 435, e1¨Ce4).

15. Liu Y, Yan B.* Characterizing the Surface Chemistry of Nanoparticles: An Analogy to Solid-Phase Synthesis Samples. Combinatorial Chemistry & High Throughput Screening 2011, 14(3), 191-197.

16. Li X, Zhou HY, Yang L, Du GQ, Pai-Panandiker A, Huang XF, and Yan B.* Enhancement of Cell Recognition in vitro by Dual-Ligand Cancer Targeting Gold Naoparticles. Biomaterials 2011, 232, 2540-2545.

17. Gasser M, Rothen-Rutishauser B, Krug HF, Gehr P, Nelle M, Yan B and Wick P. The Adsorption of Biomolecules to Multi-Walled Carbon Nanotubes is Influenced by Both Pulmonary Surfactant Lipids and Surface Chemistry. Journal of Nanobiotechnology 2010, 8:31.

18. Liu YY, Su GX, Zhang B, Jiang GB, Yan B.* Nanoparticle-Based Strategies for Detection and Remediation of Environmental Pollutants. Analyst 2011, 136(5), 872-877 (Designated by Royal Society of Chemistry as one of the top five most-read articles from the online version of Analyst for February 2011).

19. Wang GQ, Chen ZP, Wang WH, Yan B and Chen LX. Chemical Redox-Regulated Mesoporous Silica-Coated Gold Nanorods for Colorimetric Probing of Hg2+ and S2-. Analyst, 2011, 136(1), 174-178.

20. Wang F, Zhai SM, Liu XJ, Li LW, Wu S, Dou QP* and Yan B.* A Novel Dithiocarbamate Analogue with Potentially Decreased ALDH Inhibition has Copper-Dependent Proteasome-Inhibitory and Apoptosis¨CInducing Activity in Human Breast Cancer Cells. Cancer Letters 2011, 300(1), 87-95.

21. Mu, Q.X., Li, Z.W., Li, X., Mishra, M.R., Zhang, B., Si, Z.K., Yang, L., Jiang, W., Yan, B.* (2009) Characterization of Protein Clusters of Diverse Magnetic Nanoparticles and Their Dynamic Interactions with Human Cells. J Phys Chem C (In press). New!

22. Ma, X.F., Shi, R.R., Zhang, B., Yan, B.* (2009) Kinetics of Resin-Supported Mitsunobu Esterification and Etherification Reactions. J Comb Chem (In press). New!

23. Du, F.F., Zhou, H.Y., Chen, L.X., Zhang, B., Yan, B.* (2009) Structure Elucidation of Nanoparticle-Bound Organic Molecules by H NMR. Trends in Analytical Chemistry 28(1), 88-95. New!

24. Zhou, H.Y., Du, F.F., Li, X., Zhang, B., Li, W., Yan, B.* (2008) Characterization of Organic Molecules Attached to Gold Nanoparticle Surface Using High Resolution Magic Angle Spinning H NMR. J Phys Chem C 112(49), 19360-19366. New!

25. Yu, Y.M., Zhang, Q., Mu, Q.X., Zhang, B., Yan, B.* (2008) Exploring the Immunotoxicity of Carbon Nanotubes. Nanoscale Research Letters 3(8), 271-277. New!

26. Lemoff. A and Yan, B.* (2008) Dual Detection Approach to a More Accurate Measure of Relative Purity in High-Throughput Characterization of Compound Collections. J Comb Chem 10(5), 746-751. New!

27. Zhou, H.Y., Mu, Q.X., Gao, N.N., Liu, A.F., Xing, X.Y., Gao, S.L., Zhang, Q., Qu, G.B., Chen, Y.Y., Liu, G., Zhang, B., Yan, B. (2008) A Nano-Combinatorial Library Strategy for the Discovery of Nanotubes with Reduced Protein-Binding, Cytotoxicity, and Immune Response. Nano Letters 8(3), 859-865. New!

28. Qi, M.H., Zhou, H.Y., Ma, X.F., Zhang, B., Jefferies, C., Yan, B. (2008) Feasibility of a Self-Calibrated LC/MS/UV Method to Determine the Absolute Amount of Compounds in Their Storage and Screening Lifecycle. J Comb Chem 10(2), 162-165.

29. Mu, Q.X., Liu, W., Xing, Y.H., Zhou, H.Y., Li, Z.W., Zhang, Y., Ji, L.H., Wang, F., Si, Z.K., Zhang, B., Yan, B. (2008) Protein Binding by Functionalized Multiwalled Carbon Nanotubes Is Governed by the Surface Chemistry of Both Parties and the Nanotube Diameter. J Phys Chem C 112(9), 3300-3307.

30. Zhou, H.Y., Wu, S.H., Zhai, S.M., Liu, A.F., Sun, Y., Li, R.S., Zhang, Y., Ekins, S., Swaan, P.W., Fang, B.L., Zhang, B., Yan, B. (2008) Design, Synthesis, Cytoselective Toxicity, Structure-Activity Relationships, and Pharmacophore of Thiazolidinone Derivatives Targeting Drug-Resistant Lung Cancer Cell. J Med Chem 51(5), 1242-1251.

31. Zhou, H., Liu, A., Li, X., Ma, X., Feng, W., Zhang, W., Yan, B. (2008) Microwave-Assisted Fluorous Synthesis of 4-Aryl-Substituted Thiazolidinone and Thiazinanone Libraries. J Comb Chem 10(2), 303-312. Hot! (One of the Most Accessed Article 2008 from ACS Publications)

32. Zhang, B., Li, X.F., Yan, B. (2008) Advances in HPLC Detector-Towards Universal Detection. Anal Bioanal Chem 390(1), 299-301.

33. Yu, Z.Y., Wang, F., Milacic, V., Li, X.F, Cui, Q.C, Zhang, B., Yan, B., Dou, Q.P. (2007) Evaluation of Copper-Dependent Proteasome-Inhibitory and Apoptosis-Inducing Activities of Novel Pyrrolidine Dithiocarbamate Analogs. Int J Mol Med 20(6), 919-925.

34. Xu, P., Qiu, J.H., Zhang, Y.N., Chen, J., Wang, P.G., Yan, B., Song, J., Xi, R.M., Deng, Z.X., Ma, C.Q. (2007) Efficient Whole-Cell Biocatalytic Synthesis of N-Acetyl-D-Neuraminic Acid. Advanced Synthesis & Catalysis 349(10), 1614-1618.

35.Yan, B., Shi, R., Zhang, B., Kshirsagar, T. (2007) A Kinetic Study of Product Cleavage Reactions from the Solid Phase by a Biocompatible and Removable Cleaving Reagent, HCl. J Comb Chem 9(4), 684-689.

36. Shi, R., Wang, F., Yan, B. (2007) Site-Site Isolation and Site-Site Interaction - Two Sides of the Same Coin. Int J Pept Res & Therapeutics 13(1-2), 213-219.

37. Chen, D., Cui, Q.C., Yang, H., Barrea, R.A., Sarkar, F.H., Sheng, S., Yan, B., Reddy, G.P.V., Dou, Q.P. (2007) Cliquinol, a Therapeutic Agent for Alzheimer’s Disease, Has Proteasome-inhibitory, Apoptosis-inducing and Anti-tumor Activities in Human Prostate Cancer Cells and Xenografts. Cancer Res 67(4), 1636-1644.

38. Yan, B., Zhao, J., Leopold, K., Zhang, B., Jiang, G. (2007) The Structure Dependent Response of Chemiluminescence Nitrogen Detector (CLND) for Organic Compounds with Adjacent Nitrogen Atoms Connected by a Single Bond. Anal Chem 79 (2), 718-726.

39. Daniel, K.G., Chen, D., Yan, B., Dou, Q.P. (2007) Copper-Binding Compounds as Proteasome Inhibitors and Apoptosis Inducers in Human Cancer. Front Biosci 12, 135-144.

40. Zhai, S., Liu, W., Yan, B. (2007) Recent Patents on Treatment of Severe Acute Respiratory Syndrome (SARS). Recent Patents on Anti-Infective Drug Discovery 2(1), 1-10.

41. Chen, L., Choo, J., Yan, B. (2007) The Microfabricated Electrokinetic Pump: A Potential Promising Drug Delivery Technique. Expert Opin Drug Deliv 4(2), 119-129.

42. Landis-Piwowar, K.R., Milacic, V., Chen, D., Yang, H., Zhao, Z.Y., Chan, T.H., Yan, B., Dou, Q.P. (2006) Discovering Novel Anticancer Drugs and Chemo-Sensitizers by Using the Proteasome as a Potential Target. Drug Resistance Update 9, 263-273.

43. Wu, S., Guo, W., Teraishi, F., Pang, J., Kaluarachchi, K., Zhang, L., Davis, J., Dong, F., Yan, B., Fang, B. (2006) Anticancer Activity of 5-Benzylidene-2-Phenyllimino-1,3-Thiazolidin-4-one (BPT) Analogs. Med Chem 2(6), 597-605.

44. Cheng, X., Yan, B., Gao, L., Tang, H., Fan, Y., Anderson, S. N., Affleck, R., Burns, D. (2005) Compound Transfer Efficiency from Polystyrene Surfaces-Application to Micro-Arrayed Compound Screening. J Biomolecular Screening 10(4), 293-303.

45. Irving, M., Krueger, C. A., Wade, J. V., Hodges, J. C., Leopold, K., Chan, C., Shaqair, S., Shornikov, A., Stock, M., Collins, N., Yan, B. (2004) High-Throughput Purification of Combinatorial Libraries II: Automated Separation of Single Diastereomers from a 1920-Member 4-Amidopyrrolidinone Library. J Comb Chem 6, 478-486.

46. Yan, B., Collins, N., Wheatley, J., Irving, M., Leopold, K., Chan, C., Shornikov, A., Fang, L., Lee, A., Stock, M., Zhao, J. (2004) High-Throughput Purification of Combinatorial Libraries I: A High-Throughput Purification System Using an Accelerated Retention Window Approach.J Comb Chem 6, 255-261.

辽宁石油化工大学职业技术学院讲师

人物简介

性别 女

出生年月 1975.10

最终学历 研究生

职称 讲师

学 位 工学硕士

职务 教 师

所在院系 职业技术学院 机电系

讲师，1999毕业于沈阳航空工业学院信息工程专业，自参加工作起，一直从事教学工作，教学经验丰富。主讲过“数字电子技术”、“自动检测与转换技术”、“电工电子技术”等六门专业基础课程，指导过毕业设计、课程设计以及电子综合实习。在教学中经常利用多媒体、实物等辅助教学设施，教学特色鲜明。参与辽宁省教育厅教科研项目1项。撰写教研、科研论文3篇，副主编、参编高职教材2部。曾获学校青年教师讲课比赛三等奖、学院青年教师讲课比赛优秀奖等荣誉。

教学情况

一、2003－2007年讲授的主要课程

1、《自动检测与转换技术》专业课 周4学时 2005、2006、2007三届 共322人；

2、《C语言程序设计》专业基础课 周4学时 2005、2006、2007三届 共320人；

3、《电工电子技术》专业基础课 周5学时 2006、2007二届 共162人；

4、《专业英语》专业基础课 周2学时 2003、2004、2005届共256人。

二、2003－2007年承担的实践性教学

2002-2006届上述课程实验、电子实习、电工课程设计、毕业设计等共1000人。

公开出版专著

1、《电工电子技术基础》 主编 西安电子科技大学出版社 2007年；

2、《自动检测技术》 副主编 煤炭工业出版社 2007年。

公开发行的刊物上发表的教学研究论文

1、“自动化专业英语的翻译技巧” 《电大理工》2003年；

2、“如何在数字电子技术课中取得良好的教学效果”《电大理工》2004年。

获得的教学表彰/奖励

2004－2005年度学校青年教师教学比赛三等奖。