赵龙铉，1967年11月出生，药学博士，辽宁师范大学化学化工学院教授。主要从事五环三萜类药物、喹喏酮类抗菌药物和核苷类抗病毒、抗肿瘤药物的开发。

主要学习工作简历

教学工作

主持科研项目

发表论文及专利

主要学习工作简历

副教授 2003，09 – 现在 辽宁师范大学 化学化工学院

访问教授 2005，01 – 2005，12 韩国梨花女子大学 药学院（College of Pharmacy Ewha Womans University）

博士后 2001, 11 – 2003, 08 韩国化学研究院（Korea Research Institute of Chemical & Technology）

感染症治疗剂研究中心

访问研究员 2001, 03 – 2001, 10 韩国岭南大学(Yeungnam University)附属药物开发研究所

药学博士 1997, 03 – 2001, 02 韩国岭南大学（Yeungnam University）药学院　药物化学专业

助教，讲师　1993, 08 – 1997, 02 延边大学　药学院　有机化学教研室

硕士 1990, 09 – 1993, 07 延边大学　化学系　有机化学专业

学士 1986, 09 – 1990, 07 延边大学　化学系

教学工作

主要讲授课程:

本科：药物化学；药物化学实验；有机化学实验

研究生：有机药物合成原理 药物化学研究

指导研究生情况：硕士研究生7人

主持科研项目

1． 参与韩国化学研究院(KRICT)与美国NIH下属的全球结核病联盟(GATB)合作开发的结核病治疗剂前临床及候选药物合成的大型课题(Koreans Join TB Battle，Science, 2003, 300, 562)；参与多项韩国保健福址部、科技部和产资部课题。

2．主持留学归国人员启动基金和校项课题。

发表论文及专利

专利：

-Park T. H., Zhao L. X., Lee S. H., Process for Preparation of 2-Aminopyridine Derivatives, United States Patent Application Publication, US 2006/0047124 A1, 2006, Mar. 2; Korean Patent, 10-2006-0020082, 2006, Mar. 6.

近年来在期刊上发表的论文：

1. Pei X., Choi W. J., Kim Y. M., Zhao L. X. and Jeong L. S.; Synthesis of 3′-C-Hydroxymethyl-substituted Pyrimidine and Purine Nucleosides as Potential Anti-Hepatitis C Virus (HCV) Agents, Archives of Pharmacal Research, In Press, 2008

2.赵龙铉，裴晓娟，刘宁宁，刘丹竹，王迪峰；熊果醛和齐墩果醛的合成及其表征，中国材料科技与设备，In Press, 2008

3. Son J. K., Zhao L. X., Basnet A. and Lee E. S.; Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities, European Journal of Medicinal Chemistry, 43(4), 675-682, 2008

5. Jeong L. S., Tosh D. K., Kim H. O., Wang T., Hou X., Yun H. S., Kwon Y., Lee S. K., Choi J., and Zhao L. X.; First Synthesis of 4′-Selenonucleosides Showing Unusual Southern Conformation, Org. Lett., 10(2),209-212, 2008

6. Hou X., Lee H. W., Tosh D. K., Zhao L. X. and Jeong L. X.; Alternative and Improved Syntheses of Highly Potent and Selective A3 Adenosine Receptor Agonists, Cl-IB-MECA and Thio-Cl-IB-MECA, Archives of Pharmacal Research， 30(10)，1205-1209，2007

7.Wei C. X., Li F. N., Zhao L. X.and Quan Z. S.; Synthesis of 2-Substituted-7-heptyloxy-4,5-dihydro-[1,2,4]-triazolo[4,3-a]quinolin-1(2H)-ones with

Anticonvulsant Activity, Arch. Pharm. Chem. Life Sci., 340, 491-495, 2007

8.赵龙铉, 刘宁宁, 裴晓娟, 王迪峰, 刘丹竹; 熊国酸和齐墩果酸衍生物的合成与表征; 辽宁师范大学学报(自然科学版); 30(4), 476-479, 2007

9.Wang T., Lee H. J., Tosh D. K., Kim H. O., Pal S., Choi S., Lee Y., Moon H. R., Zhao L. X., Lee K. M. and Jeong L. S.; Design, synthesis, and

molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S-

adenosylhomocysteine hydrolase, Bioorg. Med. Chem. Lett. 17，4456-4459, 2007

10.Zhao L. X., Park H. G., Jew S., Lee M. K. and Lee E. S.; Modification of C11, C28, C2,3,23 or C2,23,28 Functional Groups on Asiatic Acid and

Evaluation of Hepatoprotective Effects, Bull. Korean Chem. Soc., 28(6), 970-976,2007

11. Zhao L. X., Sherchan J., Park J. K., Jahng Y. and Lee E. S.; Synthesis, Cytotoxicity and Structure-Activity Relationship Study of Terpyridines,

Archives of PharmacalResearch, 29(12), 1091-1095, 2006

12. 张雪莲，廖世军，刘军民，赵龙铉; 高含锆量的中孔分子筛 Zr-MSU-V 的合成与表征; 分子催化, 20(5), 414-418, 2006

13. Zhao L. X., Yun M. K., Kim H. O., Lee J. A., Choi W. J., Lee K. M., Lee S. K., Lee Y. B., Ahn C. H. and Jeong L. S., Design, Synthesis, and

Anticancer Activity of Fluorocyclopentenyl-pyrimidines, Nucleic Acids Symposium Series, 49, 107-108, 2005

14. Zhao L. X., Park J. G., Moon Y. S., Basnet A. and Lee E. S.; Design，Synthesis and Anticonvulsive Activity of Analogs of γ–Vinyl GABA, IL

FARMACO, 59, 381-388, 2004

15.Jahng Y. D., Zhao L. X., Moon Y. S., Basnet A. and Lee E. S.; Simple aromatic compounds containing propenone moiety show considerable dual

COX/5-LOX inhibitory activities, Bioorg. Med. Chem. Lett. 14, 2559-2562, 2004

16.Zhao L. X., Moon Y. S., Basnet A., Kim E. K. and Lee E. S.; Synthesis, Topoisomerase I inhibition and Structure-activity Relationship Study of

2,4,6-Trisubstituted Pyridine Derivatives, Bioorg. Med. Chem. Lett. 14, 1333-1337, 2004

17. Dong M. S., Jung S. H., Kim H. J., Kim J. R., Zhao L. X. and Lee E. S.; Structure-Related Cytotoxicity and Anti-Hepatofibric Effect of Asiatic Acid

Derivatives in Rat hepatic Stellate Cell-Line, HSC-T6, Archives of PharmacalResearch, 27(5), 512-517, 2004

18. ZhaoL. X., Moon Y. S., Basnet A. and Lee E. S.; Design, Synthesis and Anticonvulsive Activities of Potential Prodrugs Linked by Two-carbon

Chain,Archives of PharmacalResearch, 26(10), 785-795, 2003

19. Zhao L. X., Kim E. K., Lim H. T., Moon Y. S.and Lee E. S.; Synthesis, Characterization and In VitroIdentification of N-Guanine Adduct of 2-

Bromopropane, Archives of PharmacalResearch, 25(1), 39-44, 2002

20.Lim H. T., Moon Y. S.,ZhaoL. X., Kim E. K. and Lee E. S.; Synthesis of 7-Isopropyl Guanine as Potential DNA Adduct Derived from 2-

Bromopropane, Journal of Resource Development, 20(1), 133-137, 2002

-21. Zhao L. X., Kim T. S., Ahn S. H., Kim T. H., Kim E. K.and Lee E. S.; Synthesis, Topoisomerase I Inhibition and Antitumor Cytotoxicity of 2,2’:6’,2”-, 2,2’:6’,3”- and 2,2’:6’,4”-Terpyridine Derivatives, Bioorg. Med. Chem. Lett.11, 2659-2662，2001

22. Zhao L. X. and Lee E. S.; Synthesis of Potential Hepatoprotective Agents and Their Biological Activities, Journal of Resource Development, 20(1), 51-59, 2001

23. Zhao L. X., Kim E. K. and Lee E. S.; Asymmetric Synthesis of 2-Oxiraneboxylate Intermediate, Journal of Resource Development, 20(1), 79-86, 2001

24. Ahn S. H., Kim T. H., Zhao L. X., Kim E. K. and Lee E. S.; Synthesis and in vitro Cytotoxicity of Terpyridine Derivatives. Journal of Resource

Development, 20(1), 109-118 , 2001

25. Kim Y. C., Zhao L. X.,Kim T. H., Je S. M. and Lee E. S.; Design and Synthesis of Anticonvulsive Agents as  -Vinyl GABA-Based Potential Dual Acting Prodrugs and their Biological Activities, Bioorg. Med. Chem. Lett. 10, 609-613, 2000

-26. Jew S. S., Kim E. K., Je S. M., Zhao L. X. and Lee E. S.; Design and Synthesis of 2-Oxiranecarboxylate Derivatives and their Hypoglycemic

Activities, Heterocycles, 52(3), 1087，2000

近年来在国际学术会上发表的论文：

- Pal S., Zhao L. X., Park Y. H., Jeon J. H., Choi W. J., Lee S. K. and Jeong L. S., Design, Synthesis, and Anticancer Activity of Fluorocyclopentenyl-pyrimidines，6th AFMC International Medicinal Chemistry Symposium, Istanbul, Turkey，July 08-11，2007

- Jeong L. S., Zhao L. X., Yun M. K., Choi W. J., Lee S. K., Lee K. M, Lee Y. B., Ahn C. H., Synthesis and Anti-tumor Activity of Fluorocyclopentenyl-pyrimidines,230th American Chemical Society Meeting, Abstracts, Washington, DC, U. S. A., Aug. 28-Sept. 1, 2005

- Zhao L. X., Yun M. K., Kim H. O., Lee J. A., Choi W. J., Lee K. M., Lee S. K., Lee Y. B., Ahn C. H. and Jeong L. S., Design, Synthesis, and Anticancer Activity of Fluorocyclopentenyl-pyrimidines, 4th International Symposium on Nucleic Acids Chemistry(32nd Symposium on Nucleic Acids Chemistry in Japan), Fukuoka, Japan, September 20 – 22, 2005

- Zhao L. X., Jeong L. S., Design and Synthesis of Fluoropentenyl-pyrimidines as Potent Anticancer Agents, Proceeding of the Convention of the Pharmaceutical Society of Korea, Seoul Education Culture Center, Korea, November 28-29, 2005

- Park T.H., Lee S.H., Zhao L. X.; The generation of novel quinolone derivatives with antibacterial activity, 4th International Symposium on Antimicrobial Agents and Resistance, Seoul, Korea, July 16 – 18, 2003

- Lee E. S., Moon Y. S.,ZhaoL. X., Kim E. K., Lim H. T.; Synthesis, Characterization, In Vitro and calf Thymus DNA Identification of N-Guanine Adducts of 1- and 2-bromopropane, 42nd Annual Meeting Society of Toxicology, U. S. A., Mar. 11, 2003

- Zhao L. X., Kim E. K., Lim H. T., Moon Y. S., Kim N. H., Kim T. H., Choi H.S., Chae W. G., Jeong T. C. and Lee E. S.; Synthesis, Characterization and In VitroIdentification of N7-Guanine Adduct of 2-Bromopropane, 41st Annual Meeting Society of Toxicology, U. S. A, Mar. 19, 2002

- Lim H. T., Moon Y. S., Zhao L. X., Kim E. K., Lee E. S.; Synthesis of 2,6-Diaromatic Substituted Pyridine Derivatives and Their Antitumor Activities, Proceedings of the 51st annual convention of the pharmaceutical society of Korea, Oct. 17, 2002

- Moon Y. S., Lim H. T., Zhao L. X., Kim E. K., Lee E. S.; Design, Synthesis and Antitumor Evaluation of Terpyridine Derivatives Containing Pyridine at 4'-Position, Proceedings of the 51st annual convention of the pharmaceutical society of Korea, Oct. 17, 2002

- Zhao L. X., Kim E. K., Lim H. T., Moon Y. S., Kim N. H., Kim T. H., Choi H.S., Chae W. G., Jeong T. C. and Lee E. S.; Synthesis, Characterization, and In Vitroand Calf Thymus DNA Identification of N7-Guanine Adduct of 2-Bromopropane, Proceedings of the Spring Convention of the Pharmaceutical Society of Korea, April. 19, 2002

- Lee E. S., Zhao L. X., Ahn S. H., Kim E. K., Cho W. J., Kim T. S., Lee C. S., Lim H. T.; Synthesis of terpyridine derivatives and their topoisomerase I inhibitory activities. 221thAmerican Chemical Society Meeting, Abstracts, San Diego, U. S. A., Mar. 31-April 5, 2001

- Lee E. S., Kim J. A., Lee Y. S., Jin D. Q., Zhao L. X.; Asiatic acid, a component of Centella asiatica, and its derivatives induce appotosis in human liver cells, International Conference on Dietary Factors: Cancer Causes & Prevention, Vienna, Austria, Feb. 14, 2001

- Lee E. S., Chang C. J., Kim E. K., Kim J. A., Ahn S. H., Zhao L. X.; Synthesis and antitumor activity of terpyridine derivatives. 219th AmercianChemical Society Meeting, Abstracts, San Francisco, U. S. A., Mar. 26-31, 2000

- Lee E. S., Park H. G., Jew S. S., Ryu J. H., Kim Y. C., Lee M. K., Choi J. W., Kim T. H., ZhaoL. X. and Jahng Y. D.; Structure-activity relationship study of asiatic acid derivatives against carbontetrachloride or galactosamine-induced hepatotoxicity, 219th AmercianChemical Society Meeting, Abstracts, San Francisco, U. S. A., Mar. 26-31, 2000

- Lee E. S., Kim E. K., Kim J. A., Kim T. H., Ahn S. H., Zhao L. X., Choe J. W.; Synthesis of Pyridine, Thiophene and Furan-containing Compounds and their Antitumor Activities. The Spring Convention of the Pharmaceutical Society of Korea, April 21, 2000

- Zhao L. X.,Ahn S. H., Kim J. A., Lee E. S.; Terpyridine Derivatives: Potential Antitumor Agents, The 48th Annual Convention of the Pharmaceutical Society of Korea & International Symposium, April 21, 2000