“张幼怡”的意思、由来-中文百科全书

人物简介

张幼怡，研究员，博士生导师。北京大学第三医院血管医学研究所副所长，卫生部心血管分子生物学与调节肽重点实验室副主任，分子心血管教育部重点实验室副主任，北京大学心血管研究所所长, 北京大学前沿交叉科学研究院生物医学跨学科中心副主任。

教育背景

1992年在新疆医获医学博士学位，1994年在北京医科大学第三医院血管医学研究所博士后出站。曾在日本大学研修和美国Emory大学作博士后。

现兼任国际病理生理学会副理事长、中国病理生理学会秘书长、中国病理生理学会心血管专业委员会主任委员，中国病理生理学会受体专业委员会副主任委员，中国药理学会心血管药理专业委员会委员。《中国科学：生命科学》和《Clinical and Experimental Pharmacology and Physiology》常务编委，《J Pathophysiology》、《中国药理与毒理》、《生理学报》、《中国病理生理学杂志》、《中国药学杂志》《中华医学杂志英文版》等编委。

研究方向

1. 多种亚型肾上腺素受体在心血管共存的生理与病理意义；

2. 心血管重塑的网络调控及早期防治的基础研究；

3. 肾上腺素受体单个分子在活细胞中的动态行为；

4. 心力衰竭的分子机制与转化医学。

主要成就

多年来一直从事肾上腺素受体与心血管疾病发病机制的研究，特别是肾上腺素受体在心血管系统的分布，信号转导，生理功能及在病理状态下的改变和受体之间的交互作用的研究。作为项目主持者先后承担10 余项各级科学基金课题，包括：国家科技部重点基础研究发展规划项目“973”课题2 项(已结题)；国家自然科学基金8项，北京市自然科学基金1 项等。共发表学术论文180篇，其中SCI96篇（第一和责任作者58篇）近三年发表论文38篇，SCI 收录35篇（责任作者23篇）。2001 年获国家教委中国高校自然科学一等奖（第2 完成人）。参与编写《动态心电图》、《分子核医学》、《受体信号转导系统与疾病》和《生命科学中的单分子行为及细胞内实时检测》等著作。

近年发表的部分学术论文

1. XF Zhao, XH Zheng, YM Wei, LJ Bian, SX Wang, JB Zheng, YY Zhang*, ZJ Li, WJ Zang*. Corrigendumto “Thermodynamic study of the interaction between terbutaline and salbutamolwith an immobilized b2-adrenoceptor by high-performance liquid chromatography”. JOURNAL OF CHROMATOGRAPHY, 2009, 877:911-918

2. JY Qi, M Xu, ZZ Lv, YY Zhang*.Differential expression of 14-3-3 eduringd physiological, pathological cardisc hypertrophy and chronicheart failure in mice. GENE THERAPY AND MOLECULAR BIOLOGY, 2009, 13: 71-81

3. GM Shi, QH Cui, YY Zhang*.microRNA Set: A Novel Wayto Uncover the Potential Black box of chronic Heart Failure in MicroRNAMicroarray Analysis. JOURNAL OF COMPUTER SCIENCE & SYSTEMS BIOLOGY, 2009, 2(4):240-246

4. W Wang, M Xu, YY Zhang, B He.Fenoterol, a beta2-adrenoceptor agonist, inhibits LPS-induced membrane-boundCD14, TLR4/CD14 complex, and inflammatory cytokines production throughbeta-arrestin-2 in THP-1cell line. ACTA PHARMACOL SIN, 2009, 11, 30(11): 1522-8

5. Y Xia, KZ Gong, M Xu, YY Zhang,JH Guo, Y Song, P Zhang. Regulation of gap-junction protein connexin 43 by beta-adrenergicreceptor stimulation in rat cardiomyocytes. ACTA PHARMACOL SIN, 2009, Jul,30(7): 928-34

6. D Ai, W Pang, N Li, M Xu, PD. Jones, J Yang,YY Zhang, N Chiamvimonvate, Y. J. Shyyf, BD. Hammock, Y Zhu. Solubleepoxide hydrolase plays an essential role in angiotensin II-induced cardiachypertrophy. PNAS, 2009, 106(2): 564–569

7. ZJ Li, N Liu, LS zhang, KZ Gong, YB Cai, W Gao, ZQ Liu, SY Liu, QD Han, YY Zhang*. Proteomic profiling revealscomprehensive insights into adrenergic receptor-mediated hypertrophy inneonatal rat cardiomyocytes. PROTEOMICS CLIN APPL, 2009, 3: 1407-1421

8. JY Huang, L Qin, XL Peng, CY Xiong ,YYZhang, J Fang .Cellular traction force recovery: An optimal filteringapproach in two-dimensional fourier space. JOURNAL OF THEORETICAL BIOLOGY, 2009,7, 259: 811–819

9. JY Huang, XL Peng, L Qin, T Zhu, CY Xiong, YY Zhang, J Fang. Determination of Cellular Tractions on ElasticSubstrate Based on an Integral Boussinesq Solution. JOURNAL OF BIOMECHANICALENGINEERING, 2009, 6, 131: 061009-9

10. F Wei, Y Song, C Chen, ZZ Lv, YY Zhang*.Stimulation of adenosine A2B receptors induces interleukin-6 secretion incardiac fibroblasts via the PKC–p38 signalling pathway. BRITISH JOURNAL OFPHARMACLOLGY. 2010, 159:1598-1607

11. JY Qi, M Xu, ZZ Lv, YY Zhang*.14-3-3 inhibits IGF-I induced proliferation of cardiacfibroblasts via PI3K-dependent NFAT pathway. CLIN EXP PHARMACOL PHYSIOL, 2010,37: 296-302

12 He K,Luo W,Zhang Y,Liu F,Liu D,Xu L,Qin L,Xiong C,Lu Z,Fang X,Zhang Y*.Intercellular Transportation of Quantum Dots Mediated by Membrane Nanotubes.ACS Nano, 2010, 4 (6): 3015–3022

13. Xiao H, Ma X, Feng W, Fu Y, Lu Z, Xu M, Shen Q, Zhu Y, Zhang Y*. Metformin attenuatescardiac fibrosis by inhibiting the TGFb1-smad3signalling pathway. Cardiovasc Res , 2010: 87, 504–513

14 Jiang SY, Xu M, Ma XW, Xiao H, ZhangYY. Distinct AMPK phosphorylationsite characterizes cardiac hypertrophy induced by L-thyroxine andangiotensinII. Clin ExpPharmacol Physiol, 2010:37;919–925

15 Xiao H, Zhang YY, Du XJ, Lu ZZ. Developmental changes in the geometry, functionand responsiveness of the mouse heart to β-adrenergic stimulation as determinedby high-resolution echocardiography. Clin Exp Pharmacol Physiol.2010;37:826-832

16. Liu X, Gai Y, Liu F, Gao W, Zhang Y, Xu M, Li Z. Trimetazidineinhibits pressure overload-induced cardiac fibrosis through NADPHoxidase-ROS-CTGF pathway. Cardiovasc Res. 2010;88:150-158

17. Zhao X, Nan Y, Xiao C, Zheng J, ZhengX*, Wei Y, Zhang Y*. Screening thebioactive compounds in aqueous extract of Coptidis rhizoma which specificallybind to rabbit lung tissues beta2-adrenoceptor using an affinitychromatographic selection method.J Chromatogr B Analyt Technol Biomed Life Sci.2010 Jul 15;878(22):2029-34

18. He K, Fu Y, Zhang W, Yuan J, Li Z, Lv Z, Zhang Y*, Fang X. Single-molecule imaging revealed enhanceddimerization of transforming growth factor β type Ⅱreceptors in hypertrophiccardiomyocytes. Biochem Biophys Res Commun. 2011;407(2):313-7

19. Ma X, Song Y, Chen C, Fu Y, Shen Q, Li Z,Zhang Y.* Distinct actions of intermittent and sustained b-adrenoceptor stimulation on cardiac remodeling. Sci China Life Sci. 2011;54(6):493-501

20. Shi X,Qin L,Zhang X,He K,Xiong C,Fang J,Fang X,Zhang Y*.Elasticity of cardiac cells on the polymer substrates with different stiffness:an atomic force microscopy study. Phys Chem Chem Phys.2011;13(16):7540-5

21. Fu YN,Xiao H,Ma XW,Jiang SY,Xu M,Zhang YY*. Metformin attenuates pressureoverload-induced cardiac hypertrophy via AMPK activation. Acta Pharmacol Sin. 2011;32(7):879-87

22. Liu F, He K, Yang X, Xu N, Liang Z, Xu M, Zhao XS, Han QD, zhang YY*. 1A-Adrenergic receptor induces activation ofextracellular signal-regulated kinase 1/2 through endocytic pathway. PLoS ONE 2011;6(6): e21520

23. He K, Shi X, Zhang X, Ma X, Liu F, Xu M, LvZ, Fang X, Zhang Y*. Long-distance intercellular connectivity between cardiomyocytes andcardiofibroblasts mediated by membrane nanotubes. Cardiovasc Res. 2011; 92, 39–47

24. Li Z, Liu N, Han Q, Zhang Y*. A proteome reference map andregulation network of the neonatal rat cardiomyocyte. Acta Pharmacologica Sinica，2011; 32(9):1116-27

25. Li Y, Zhang H, Liao W, Song Y, Ma X, Chen C, Lü Z, Li Z, Zhang Y*. Transactivated EGFR mediatesα1-AR-induced STAT3 activation and cardiac hypertrophy. Am J PhysiolHeart Circ Physiol. 2011;301(5):H1941-51

26. Xu Q,Dalic A,Fang L,Kiriazis H,Ritchie RH,Sim K,Gao XM,Drummond G,Sarwar M,Zhang YY,Dart AM,Du XJ.Myocardial oxidative stress contributes to transgenic β-adrenoceptoractivation-induced cardiomyopathy and heart failure. Br J Pharmacol. 2011Mar;162(5):1012-28

27. Wang J,Song Y,Zhang Y,Xiao H,Sun Q,Hou N,Guo S,Wang Y,Fan K,Zhan D,Zha L,Cao Y,Li Z,Cheng X,Zhang Y*,Yang X.Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy anddysfunction in mice. Cell Research, 2011 Aug 16. doi: 10.1038/cr.2011.132

28. Chen C, Du J, Feng W, Song Y, Lu Z, Xu M, LiZ, Zhang Y*. b-adrenergic receptors stimulate interleukin-6 production throughEpac-dependent activation of PKCd/p38 MAPKsignaling in neonatal mouse cardiac fibroblasts. Br J Pharmacol, 2011 Nov 21.doi: 10.1111/j.1476-5381.2011.01785.x.

29. Yongnan Fu, Han Xiao, YouyiZhang*. β-adrenoceptor signaling pathways mediate cardiac pathologicalremodeling. FRONTIERS IN BIOSCIENCE. 2012 Jan 1;4:1625-37

词条	张幼怡
释义	人物简介教育背景社会兼职研究方向主要成就近年发表的部分学术论文人物简介张幼怡，研究员，博士生导师。北京大学第三医院血管医学研究所副所长，卫生部心血管分子生物学与调节肽重点实验室副主任，分子心血管教育部重点实验室副主任，北京大学心血管研究所所长, 北京大学前沿交叉科学研究院生物医学跨学科中心副主任。教育背景 1992年在新疆医获医学博士学位，1994年在北京医科大学第三医院血管医学研究所博士后出站。曾在日本大学研修和美国Emory大学作博士后。社会兼职现兼任国际病理生理学会副理事长、中国病理生理学会秘书长、中国病理生理学会心血管专业委员会主任委员，中国病理生理学会受体专业委员会副主任委员，中国药理学会心血管药理专业委员会委员。《中国科学：生命科学》和《Clinical and Experimental Pharmacology and Physiology》常务编委，《J Pathophysiology》、《中国药理与毒理》、《生理学报》、《中国病理生理学杂志》、《中国药学杂志》《中华医学杂志英文版》等编委。研究方向 1. 多种亚型肾上腺素受体在心血管共存的生理与病理意义； 2. 心血管重塑的网络调控及早期防治的基础研究； 3. 肾上腺素受体单个分子在活细胞中的动态行为； 4. 心力衰竭的分子机制与转化医学。主要成就多年来一直从事肾上腺素受体与心血管疾病发病机制的研究，特别是肾上腺素受体在心血管系统的分布，信号转导，生理功能及在病理状态下的改变和受体之间的交互作用的研究。作为项目主持者先后承担10 余项各级科学基金课题，包括：国家科技部重点基础研究发展规划项目“973”课题2 项(已结题)；国家自然科学基金8项，北京市自然科学基金1 项等。共发表学术论文180篇，其中SCI96篇（第一和责任作者58篇）近三年发表论文38篇，SCI 收录35篇（责任作者23篇）。2001 年获国家教委中国高校自然科学一等奖（第2 完成人）。参与编写《动态心电图》、《分子核医学》、《受体信号转导系统与疾病》和《生命科学中的单分子行为及细胞内实时检测》等著作。近年发表的部分学术论文 1. XF Zhao, XH Zheng, YM Wei, LJ Bian, SX Wang, JB Zheng, YY Zhang, ZJ Li, WJ Zang. Corrigendumto “Thermodynamic study of the interaction between terbutaline and salbutamolwith an immobilized b2-adrenoceptor by high-performance liquid chromatography”. JOURNAL OF CHROMATOGRAPHY, 2009, 877:911-918 2. JY Qi, M Xu, ZZ Lv, YY Zhang.Differential expression of 14-3-3 eduringd physiological, pathological cardisc hypertrophy and chronicheart failure in mice. GENE THERAPY AND MOLECULAR BIOLOGY, 2009, 13: 71-81 3. GM Shi, QH Cui, YY Zhang.microRNA Set: A Novel Wayto Uncover the Potential Black box of chronic Heart Failure in MicroRNAMicroarray Analysis. JOURNAL OF COMPUTER SCIENCE & SYSTEMS BIOLOGY, 2009, 2(4):240-246 4. W Wang, M Xu, YY Zhang, B He.Fenoterol, a beta2-adrenoceptor agonist, inhibits LPS-induced membrane-boundCD14, TLR4/CD14 complex, and inflammatory cytokines production throughbeta-arrestin-2 in THP-1cell line. ACTA PHARMACOL SIN, 2009, 11, 30(11): 1522-8 5. Y Xia, KZ Gong, M Xu, YY Zhang,JH Guo, Y Song, P Zhang. Regulation of gap-junction protein connexin 43 by beta-adrenergicreceptor stimulation in rat cardiomyocytes. ACTA PHARMACOL SIN, 2009, Jul,30(7): 928-34 6. D Ai, W Pang, N Li, M Xu, PD. Jones, J Yang,YY Zhang,** N Chiamvimonvate, Y. J. Shyyf, BD. Hammock, Y Zhu. Solubleepoxide hydrolase plays an essential role in angiotensin II-induced cardiachypertrophy. PNAS, 2009, 106(2): 564–569 7. ZJ Li, N Liu, LS zhang, KZ Gong, YB Cai, W Gao, ZQ Liu, SY Liu, QD Han, YY Zhang. Proteomic profiling revealscomprehensive insights into adrenergic receptor-mediated hypertrophy inneonatal rat cardiomyocytes. PROTEOMICS CLIN APPL, 2009, 3: 1407-1421 8. JY Huang, L Qin, XL Peng, CY Xiong ,YYZhang, J Fang .Cellular traction force recovery: An optimal filteringapproach in two-dimensional fourier space. JOURNAL OF THEORETICAL BIOLOGY, 2009,7, 259: 811–819 9. JY Huang, XL Peng, L Qin, T Zhu, CY Xiong, YY Zhang, J Fang. Determination of Cellular Tractions on ElasticSubstrate Based on an Integral Boussinesq Solution. JOURNAL OF BIOMECHANICALENGINEERING, 2009, 6, 131: 061009-9 10. F Wei, Y Song, C Chen, ZZ Lv, YY Zhang*.Stimulation of adenosine A2B receptors induces interleukin-6 secretion incardiac fibroblasts via the PKC–p38 signalling pathway. BRITISH JOURNAL OFPHARMACLOLGY. 2010, 159:1598-1607 11. JY Qi, M Xu, ZZ Lv, YY Zhang.14-3-3 inhibits IGF-I induced proliferation of cardiacfibroblasts via PI3K-dependent NFAT pathway. CLIN EXP PHARMACOL PHYSIOL, 2010,37: 296-302 12 He K,Luo W,Zhang Y,Liu F,Liu D,Xu L,Qin L,Xiong C,Lu Z,Fang X,Zhang Y.Intercellular Transportation of Quantum Dots Mediated by Membrane Nanotubes.ACS Nano, 2010, 4 (6): 3015–3022 13. Xiao H, Ma X, Feng W, Fu Y, Lu Z, Xu M, Shen Q, Zhu Y, Zhang Y. Metformin attenuatescardiac fibrosis by inhibiting the TGFb1-smad3signalling pathway. Cardiovasc Res , 2010: 87, 504–513 14 Jiang SY, Xu M, Ma XW, Xiao H, ZhangYY. Distinct AMPK phosphorylationsite characterizes cardiac hypertrophy induced by L-thyroxine andangiotensinII. Clin ExpPharmacol Physiol, 2010:37;919–925 15 Xiao H, Zhang YY, Du XJ, Lu ZZ. Developmental changes in the geometry, functionand responsiveness of the mouse heart to β-adrenergic stimulation as determinedby high-resolution echocardiography. Clin Exp Pharmacol Physiol.2010;37:826-832 16. Liu X, Gai Y, Liu F, Gao W, Zhang Y, Xu M, Li Z. Trimetazidineinhibits pressure overload-induced cardiac fibrosis through NADPHoxidase-ROS-CTGF pathway. Cardiovasc Res. 2010;88:150-158 17. Zhao X, Nan Y, Xiao C, Zheng J, ZhengX, Wei Y, Zhang Y. Screening thebioactive compounds in aqueous extract of Coptidis rhizoma which specificallybind to rabbit lung tissues beta2-adrenoceptor using an affinitychromatographic selection method.J Chromatogr B Analyt Technol Biomed Life Sci.2010 Jul 15;878(22):2029-34 18. He K, Fu Y, Zhang W, Yuan J, Li Z, Lv Z, Zhang Y*, Fang X. Single-molecule imaging revealed enhanceddimerization of transforming growth factor β type Ⅱreceptors in hypertrophiccardiomyocytes. Biochem Biophys Res Commun. 2011;407(2):313-7 19. Ma X, Song Y, Chen C, Fu Y, Shen Q, Li Z,Zhang Y.* Distinct actions of intermittent and sustained b-adrenoceptor stimulation on cardiac remodeling. Sci China Life Sci. 2011;54(6):493-501 20. Shi X,Qin L,Zhang X,He K,Xiong C,Fang J,Fang X,Zhang Y*.Elasticity of cardiac cells on the polymer substrates with different stiffness:an atomic force microscopy study. Phys Chem Chem Phys.2011;13(16):7540-5 21. Fu YN,Xiao H,Ma XW,Jiang SY,Xu M,Zhang YY*. Metformin attenuates pressureoverload-induced cardiac hypertrophy via AMPK activation. Acta Pharmacol Sin. 2011;32(7):879-87 22. Liu F, He K, Yang X, Xu N, Liang Z, Xu M, Zhao XS, Han QD, zhang YY*. 1A-Adrenergic receptor induces activation ofextracellular signal-regulated kinase 1/2 through endocytic pathway. PLoS ONE 2011;6(6): e21520 23. He K, Shi X, Zhang X, Ma X, Liu F, Xu M, LvZ, Fang X, Zhang Y*. Long-distance intercellular connectivity between cardiomyocytes andcardiofibroblasts mediated by membrane nanotubes. Cardiovasc Res. 2011; 92, 39–47 24. Li Z, Liu N, Han Q, Zhang Y*. A proteome reference map andregulation network of the neonatal rat cardiomyocyte. Acta Pharmacologica Sinica，2011; 32(9):1116-27 25. Li Y, Zhang H, Liao W, Song Y, Ma X, Chen C, Lü Z, Li Z, Zhang Y*. Transactivated EGFR mediatesα1-AR-induced STAT3 activation and cardiac hypertrophy. Am J PhysiolHeart Circ Physiol. 2011;301(5):H1941-51 26. Xu Q,Dalic A,Fang L,Kiriazis H,Ritchie RH,Sim K,Gao XM,Drummond G,Sarwar M,Zhang YY*,Dart AM,Du XJ.Myocardial oxidative stress contributes to transgenic β-adrenoceptoractivation-induced cardiomyopathy and heart failure. Br J Pharmacol. 2011Mar;162(5):1012-28 27. Wang J,Song Y,Zhang Y,Xiao H,Sun Q,Hou N,Guo S,Wang Y,Fan K,Zhan D,Zha L,Cao Y,Li Z,Cheng X,Zhang Y,Yang X.Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy anddysfunction in mice. Cell Research, 2011 Aug 16. doi: 10.1038/cr.2011.132 28. Chen C, Du J, Feng W, Song Y, Lu Z, Xu M, LiZ, Zhang Y. b-adrenergic receptors stimulate interleukin-6 production throughEpac-dependent activation of PKCd/p38 MAPKsignaling in neonatal mouse cardiac fibroblasts. Br J Pharmacol, 2011 Nov 21.doi: 10.1111/j.1476-5381.2011.01785.x. 29. Yongnan Fu, Han Xiao, YouyiZhang. β-adrenoceptor signaling pathways mediate cardiac pathologicalremodeling. FRONTIERS IN BIOSCIENCE. 2012 Jan 1;4:1625-37
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人物简介

教育背景

社会兼职

研究方向

主要成就

近年发表的部分学术论文