张庆柱，男，汉族，1956年生，山东济宁市人，中国医学科学院·中国协和医科大学神经药理学博士研究生毕业，赴日本新潟药学和应用生命科学大学（Niigata University of Pharmacy and Applied Life Sciences）做研究工作一年。

个人履历

成就及荣誉

个人履历

现为山东大学药学院药理学教授，博士生导师，临床药学系主任。兼职中国药理学会神经药理专业委员会委员，山东药理学会常务理事，《山东药理学通讯》主编。

成就及荣誉

发表学术论文百余篇，10余篇英文原著被SCI收载或引用。获山东省科学技术进步奖、省高校优秀科研成果奖励8项。

主编的著作和教材有《神经药理学研究技术与方法》（人民卫生出版社，2005年3月），《基础药理学》（高等教育出版社，2006年6月），《书写世界现代医学史的巨人们-历届诺贝尔生理学或医学奖获得者的传奇业绩和人生》（中国协和医科大学出版社，2006年6月），《分子药理学》（高等教育出版社，2007年5月），《神经药理学》（人民卫生出版社，2008年2月）。另外，主译著作1部，副主编专著1部，参编著作1部，参编教材或教学参考书8本。

主要从事细胞内Ca2+调控与神经系统疾病的关系探讨，以及ULMWH抗脑缺血、抗AD作用及其机制的系列研究。

近年来发表的论文和出版的著作主要有：

1. Zhi-guo ZHANG, Qing-zhu ZHANG（张庆柱）, Yan-na CHENG, Sheng-li JI, Guan-hua DU. Antagonistic effects of Ultra-Low-Molecular-Weight Heparin against cerebral ischemia/ reperfusion injury in rats. Pharmacological Research（Pharmacol Res），2007；56（4）：350-355.

2. Dakshnamurthy Selvakumar, Qing-Zhu Zhang（张庆柱），Masabiko Miyamota, Yasuhiro Furuichi, Tadazumi Komiyama. Identification and Characterization of a Neutralizing Monoclonal Antibody for the Epitope on HM-1Killer Toxin. J Biochem 2006; 139(10): 399-406.

3. Yong Cheng, Zheng Feng, Qing-Zhu Zhang（张庆柱）, Jun-tian Zhang. Beneficial Effects of Melatonin in Experimental Models of Alzheimer's Disease. Acta Pharmacol Sin 2006; 27 (2): 129-139.

4. Tadazumi Komiyama, Zhang Qingzhu（张庆柱）, Masahiko Miyamoto, Dakshnamurthy Selvakumar, and Yasuhiro Furuichi. Monoclonal Antibodies and Sandwich ELISA for Quantitation of HM-1 Killer Toxin. Biol Pharm Bull 2004; 27(5): 691-693.

5. Yao Jing-Chun, Zhang Qingzhu（张庆柱）. Inhibitory effects of melatonin on the elevation of CD45 expression induced by hypoxia in BV-2 microglia. Chin Pharmacol Toxicol 2004; 13(4): 259.

6. SUN Hua, ZHANG Qing-Zhu et al. Effects of diacetyl guan fu base A on pacemaker cells in sinoatrial node of rabbits. Acta Pharmacol Sin 2002;23(7): 627-630.

7. Wang lizan，Zhang Qingzhu et al. Anti-endotoxic shock effects of cyproheptadine in rats. Chin Med J 2002; 115(3):443-445.

8. Wang lizan，Zhang Qingzhu et al. Verapamil，cyproheptadine and anisodamine antagonized [Ca2+]i elevation induced by TNFαin a single endothelial cell. Acta Pharmacol Sin 2001;22(10): 918-922.

9. Zhang Qingzhu（张庆柱）, Zhang Juntian. Effects of melatonin on the spatial and temporal changes of [Ca2+]i in single living cell of cortical neyrons by laser scanning confocal microscopy. Chin Med J 2000; 113(6):558-562.

10. Zhang Qingzhu（张庆柱）, Zhang Juntian. Antagonistic effects of melatonin on glutamate release and neurotoxicity in cerebral cortex. Acta Pharmacol Sin 1999; 20(9): 829-834

11．张均田，张庆柱主编。《神经药理学研究技术与方法》。第一版，北京：人民卫生出版社，2005年3月。

12．张庆柱，张均田主编。《书写世界现代医学史的巨人们-历届诺贝尔生理学或医学奖获得者的传奇业绩和人生》。第一版，北京：中国协和医科大学出版社，2006年6月。

13．张庆柱主编。《基础药理学》。第一版，北京：高等教育出版社，2006年6月。

14．张庆柱主编。《分子药理学》。第一版，北京：高等教育出版社。2007年5月。

15．张均田，张庆柱，张永祥主编。《神经药理学》。第一版，北京：人民卫生出版社，2008年2月。

Professor of Pharmacology, Director of Department of Clinical Pharmacy

Faculty of Pharmaceutical Sciences, Shandong University

Institute of Pharmacology of New drugs

Faculty of Pharmaceutial Sciences, Western Campus of Shandong University

No. 7 Building, No. 44 Wenhua Xi Road

Jinan 250012, Shandong Province, P. R. China.

PROFILE

Qingzhu Zhang is the Male, the Han Nationality, born in Jinning city of Shandong province on Sept.24, 1956. B.S., graduated from major in medicine.of Qingdao Medical College in 1983. In 1999, he obtained his Ph.D. of Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC). Now, he is Prof. in Pharmacology, the tutor of Ph.D. student, and the director of Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Shandong University. He also is the member in Neuropharmacological Committee of the Chinese Pharmacological Society, and the member of standing council of Shandong Pharmacological Society. His research direction is Neuropharmacology, including the effects and mechanisms of melatonin, antioxidants and calcium antagonists on brain disorders or the aged diseases, especially in the relations between antagonists of inositol trisphosphate (IP3) receptor and Ca2+-modulated intracellular Ca2+ releases, and the treatment of Alzheimer’s disease. He holds the second, and third awards of Science and Technology Progressive Prizes (Government and Educational Committee of Shandong Province). 10 academic books were published, two of them in chief-in-editor. The more than 80 of academic articles (70 papers of the first author) had been published in Acta Pharmacol Sin, Chin Med J, Acta Pharm, Chin Pharmacol Toxicol etc., respectively. 10 papers of them were collected and cited in SCI.

DEGREE

Ph.D., Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC)

PRINCIPAL PUBLICATIONS

1. Zhi-guo ZHANG, Qing-zhu ZHANG（张庆柱）, Yan-na CHENG, Sheng-li JI, Guan-hua DU. Antagonistic effects of Ultra-Low-Molecular-Weight Heparin against cerebral ischemia/ reperfusion injury in rats. Pharmacological Research（Pharmacol Res），2007；56（4）：350-355.

2. Dakshnamurthy Selvakumar, Qing-Zhu Zhang（张庆柱），Masabiko Miyamota, Yasuhiro Furuichi, Tadazumi Komiyama. Identification and Characterization of a Neutralizing Monoclonal Antibody for the Epitope on HM-1Killer Toxin. J Biochem 2006; 139(10): 399-406.

3. Yong Cheng, Zheng Feng, Qing-Zhu Zhang（张庆柱）, Jun-tian Zhang. Beneficial Effects of Melatonin in Experimental Models of Alzheimer's Disease. Acta Pharmacol Sin 2006; 27 (2): 129-139.

4. Tadazumi Komiyama, Zhang Qingzhu（张庆柱）, Masahiko Miyamoto, Dakshnamurthy Selvakumar, and Yasuhiro Furuichi. Monoclonal Antibodies and Sandwich ELISA for Quantitation of HM-1 Killer Toxin. Biol Pharm Bull 2004; 27(5): 691-693.

5. Yao Jing-Chun, Zhang Qingzhu（张庆柱）. Inhibitory effects of melatonin on the elevation of CD45 expression induced by hypoxia in BV-2 microglia. Chin Pharmacol Toxicol 2004; 13(4): 259.

6. SUN Hua, ZHANG Qing-Zhu et al. Effects of diacetyl guan fu base A on pacemaker cells in sinoatrial node of rabbits. Acta Pharmacol Sin 2002;23(7): 627-630.

7. Wang lizan，Zhang Qingzhu et al. Anti-endotoxic shock effects of cyproheptadine in rats. Chin Med J 2002; 115(3):443-445.

8. Wang lizan，Zhang Qingzhu et al. Verapamil，cyproheptadine and anisodamine antagonized [Ca2+]i elevation induced by TNFαin a single endothelial cell. Acta Pharmacol Sin 2001;22(10): 918-922.

9. Zhang Qingzhu（张庆柱）, Zhang Juntian. Effects of melatonin on the spatial and temporal changes of [Ca2+]i in single living cell of cortical neyrons by laser scanning confocal microscopy. Chin Med J 2000; 113(6):558-562.

10. Zhang Qingzhu（张庆柱）, Zhang Juntian. Antagonistic effects of melatonin on glutamate release and neurotoxicity in cerebral cortex. Acta Pharmacol Sin 1999; 20(9): 829-834

11. Zhang JT and Zhang QZ. Technology and Methodology of Neuropharmacological Research. 1st ed. People’s Medical Publishing House, 2005 (Chinese reference book).

12. Zhang QZ ed. Basic Pharmacology. 1st ed. Higher Education Press, 2006 (Chinese textbook).

13. Zhang QZ and Zhang JT. The Great Masters Creating World’s Modern Medical History—The Outstanding Achievement and Legendary Life of 105 Years’ Nobel Prize Winners in Physiology or Medicine. 1st ed. Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC) Press. 2006 (A Chinese book of popular medical sciences).

14. Zhang QZ ed. Molecular Pharmacology. 1st ed. Higher Education Press, 2007 (Chinese textbook).

15. Zhang JT，Zhang QZ and Zhang YX. Neuropharmacology. 1st ed. People’s Medical Publishing House, 2008 (Chinese reference book).