“王任小”的意思、由来-中文百科全书

1. Cheng, T.; Zhao, Y.; Li, X.; Lin, F.; Xu, Y.; Zhang, X.; Li, Y.; Wang, R.*; Lai, L. “Computation of Octanol-Water Partition Coefficients by Guiding an Additive Model with Knowledge”, J. Chem. Inf. Model. 2007, 47, ASAP.

2. Zhao, Y.; Cheng, T.; Wang, R.* “Automatic Perception of Organic Molecules Based on Essential Structural Information”, J. Chem. Inf. Model. 2007, 47, 1379-1385.

3. Wang, R.*; Lin, F.; Xu, Y.; Cheng, T. “I-SOLV: A new surface-based empirical model for computing solvation free energies”, J. Mol. Graph. Model. 2007, 26, 368-377.

4. Feng, D.-J.; Wang, G..-T.; Wu, J.; Wang, R.-X.; Li, Z.-T. “Hydrogen bonding-driven elastic bis(zinc)porphyrin receptors for neutral and cationic electron-deficient guests with a sandwich-styled complexing pattern”, Tetrahedron Lett. 2007, 48, 6181-6185.

5. Li, C.; Wang, G.; Yi, H.; Jiang, X.; Li, Z.*; Wang, R.* “Diastereomeric Recognition of Chiral Foldamer Receptors for Chiral Glucoses”, Org. Lett. 2007, 9, 1797-1800.

6. Ma, D.; Yu, S.; Li, B.; Chen, L.; Chen, R.; Yu, K.; Zhang, L.; Chen, Z.; Zhong, D.; Gong, Z.; Wang, R.; Jiang, H.; Pei, G. “Synthesis and Biological Evaluation of 1,3,3,4-Tetrasubstituted Pyrrolidine CCR5 Receptor Antagonists. Discovery of a Potent and Orally Bioavailable Anti-HIV Agent”, ChemMedChem, 2007, 2, 187-193.

7. Tang, G.; Ding, K.; Nikolovska-Coleska, Z.; Yang, C.-Y.; Qiu, S.; Shangary, S.; Wang, R.; Guo, J.; Gao, W.; Meagher, J.; Stuckey, J.; Krajewski, K.; Jiang, S.; Roller, P. P.; Wang, S. “Structure-Based Design of Flavonoid Compounds As a New Class of Small-Molecule Inhibitors of the Anti-apoptotic Bcl-2 Proteins”, J. Med. Chem. 2007, 50, 3163-3166.

8. Tang, G.-Z.; Yang, C.-Y.; Nikolovska-Coleska, Z.; Guo, J.; Qiu, S.; Wang, R.-X.; Gao, W.; Wang, G.-P.; Stuckey, J.; Krajewski, K.; Jiang, S.; Roller, P. P.; Wang, S.-M. “Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins”, J. Med. Chem. 2007, 50, 1723-1726.

9. Lu, Y.; Wang, R.; Yang, C.-Y.; Wang, S. “Analysis of ligand-bound water molecules in high-resolution crystal structures of protein-ligand complexes”. J. Chem. Inf. Model. 2007, 47, 668-675.

10. Xu, Y.; Wang, R.* “A Computational Analysis of the Binding Affinities of FKBP12 Inhibitors Using the MM-PB/SA Method”, Proteins, 2006, 64, 1058-1068.

11. Yu, S.; Pu, X.; Cheng, T.; Wang, R.; Ma, D. “Total Synthesis of Clavepictines A and B and Pictamine”, Org. Lett. 2006, 8, 3179-3182.

12. Ma, D.; Jiang, Y.; Chen, F.; Gong, L.-k.; Ding, K.; Xu, Y.; Wang, R.; Ge, A.; Ren, J.; Li, J.; Li, J.; Ye, Q. “Selective Inhibition of Matrix Metalloproteinase Isozymes and in Vivo Protection against Emphysema by Substituted -Keto Carboxylic Acids”, J. Med. Chem. 2006, 49, 456-458.

13. Wang, G.; Nikolovska-Coleska, Z.; Yang, C.-Y.; Wang, R.; Tang, G.; Guo, J.; Shangary, S.; Qiu, S.; Gao, W.; Yang, D.; Meagher, J.; Stuckey, J.; Krajewski, K.; Jiang, S.; Roller, P. P.; Abaan, H. O.; Tomita, Y.; Wang, S. “Structure-Based Design of Potent Small-Molecule Inhibitors of Anti-Apoptotic Bcl-2 Proteins”, J. Med. Chem., 2006, 49, 6139-6142.

14. Yang, C.-Y.; Wang, R.; Wang, S. “M-Score: A Knowledge-Based Potential Scoring Function Accounting for Protein Atom Mobility”, J. Med. Chem. 2006, 49, 5903-5911.

15. Wang, R.; Fang, X.; Lu, Y.; Yang, C.-Y.; Wang, S. “The PDBbind Database: Methodologies and Updates”, J. Med. Chem. 2005, 48, 4111-4119.

16. Yang, C.-Y.; Wang, R.; Wang, S. “A Systematic Analysis of the Effect of Small-Molecule Binding on Protein Flexibility of the Ligand-Binding Sites”, J. Med. Chem. 2005, 48, 5648-5650.

17. Song, H.; Wang, R.; Wang, S; Lin, J. “A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells”, Proc. Natl. Acad. Sci. 2005, 102, 4700-4705.

18. Wang R.; Lu Y.; Fang X.; Wang S. “An Extensive Test of 14 Scoring Functions Using the PDBbind Refined Set of 800 Protein-Ligand Complexes”, J. Chem. Inf. Comput. Sci. 2004, 44, 2114-2125.

19. Real P.J.; Cao, Y.; Wang R.; Nikolovska-Coleska Z.; Sanz-Ortiz J.; Wang S.; Fernandez-Luna J. L. “Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2”, Cancer Research, 2004, 64, 7947-7953.

20. Wang, R.; Fang, X.; Lu, Y.; Wang, S. “The PDBbind Database: Collection of Binding Affinities for Protein-Ligand Complexes with Known Three-Dimensional Structures”, J. Med. Chem. 2004, 47, 2977-2980.

词条	王任小
释义	王任小，男，1972年04月生，1994年09月师从北京大学唐有祺教授，于1999年07月获得博士学位。“百人计划”研究员，课题组长。2001年9月至2005年7月：美国密西根大学（University of Michigan）医学院，research investigator 2000年9月至2001年8月：美国乔治敦大学（Georgetown University）癌症中心，postdoctoral fellow 1999年9月至2000年8月：美国加州大学洛杉矶分校(University of California Los Angeles)化学系， postdoctoral fellow 基本情况研究方向工作经历教育背景主要获奖情况主要论文基本情况王任小，男，1972年04月生，1994年09月师从北京大学唐有祺教授，于1999年07月获得博士学位。“百人计划”研究员，课题组长。研究方向计算化学生物学以分子模拟、生物信息学和化学信息学为手段，研究重要生物大分子的功能和机制，研究有机小分子和生物大分子相互作用的基本理论，发展和完善计算机辅助药物设计方法。以与重大疾病过程相关的生物大分子作为靶标，运用计算机辅助药物设计方法并结合必要的化学和生物实验手段，寻找和设计可以有效调节这些靶标分子功能的有机小分子化合物。承担的主要科研项目目前承担或参与国家自然科学基金委、科技部、中国科学院以及上海市科委在研项目多项。工作经历 2005年8月至今：中国科学院上海有机化学研究所，“百人计划”研究员 2001年9月至2005年7月：美国密西根大学（University of Michigan）医学院，research investigator 2000年9月至2001年8月：美国乔治敦大学（Georgetown University）癌症中心，postdoctoral fellow 1999年9月至2000年8月：美国加州大学洛杉矶分校(University of California Los Angeles)化学系， postdoctoral fellow 教育背景 1994年9月至1999年7月：北京大学物理化学研究所，理学博士，导师：唐有祺院士 1989年9月至1994年7月：北京大学化学系，理学学士，导师：来鲁华教授主要获奖情况 2001年，美国Cap CURE癌症基金会Young Investigator Award 2001年，中国教育部“全国优秀博士学位论文” 主要论文 2000年以来发表的论文清单 1. Cheng, T.; Zhao, Y.; Li, X.; Lin, F.; Xu, Y.; Zhang, X.; Li, Y.; Wang, R.; Lai, L. “Computation of Octanol-Water Partition Coefficients by Guiding an Additive Model with Knowledge”, J. Chem. Inf. Model. 2007, 47, ASAP. 2. Zhao, Y.; Cheng, T.; Wang, R. “Automatic Perception of Organic Molecules Based on Essential Structural Information”, J. Chem. Inf. Model. 2007, 47, 1379-1385. 3. Wang, R.; Lin, F.; Xu, Y.; Cheng, T. “I-SOLV: A new surface-based empirical model for computing solvation free energies”, J. Mol. Graph. Model. 2007, 26, 368-377. 4. Feng, D.-J.; Wang, G..-T.; Wu, J.; Wang, R.-X.; Li, Z.-T. “Hydrogen bonding-driven elastic bis(zinc)porphyrin receptors for neutral and cationic electron-deficient guests with a sandwich-styled complexing pattern”, Tetrahedron Lett. 2007, 48, 6181-6185. 5. Li, C.; Wang, G.; Yi, H.; Jiang, X.; Li, Z.; Wang, R.* “Diastereomeric Recognition of Chiral Foldamer Receptors for Chiral Glucoses”, Org. Lett. 2007, 9, 1797-1800. 6. Ma, D.; Yu, S.; Li, B.; Chen, L.; Chen, R.; Yu, K.; Zhang, L.; Chen, Z.; Zhong, D.; Gong, Z.; Wang, R.; Jiang, H.; Pei, G. “Synthesis and Biological Evaluation of 1,3,3,4-Tetrasubstituted Pyrrolidine CCR5 Receptor Antagonists. Discovery of a Potent and Orally Bioavailable Anti-HIV Agent”, ChemMedChem, 2007, 2, 187-193. 7. Tang, G.; Ding, K.; Nikolovska-Coleska, Z.; Yang, C.-Y.; Qiu, S.; Shangary, S.; Wang, R.; Guo, J.; Gao, W.; Meagher, J.; Stuckey, J.; Krajewski, K.; Jiang, S.; Roller, P. P.; Wang, S. “Structure-Based Design of Flavonoid Compounds As a New Class of Small-Molecule Inhibitors of the Anti-apoptotic Bcl-2 Proteins”, J. Med. Chem. 2007, 50, 3163-3166. 8. Tang, G.-Z.; Yang, C.-Y.; Nikolovska-Coleska, Z.; Guo, J.; Qiu, S.; Wang, R.-X.; Gao, W.; Wang, G.-P.; Stuckey, J.; Krajewski, K.; Jiang, S.; Roller, P. P.; Wang, S.-M. “Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins”, J. Med. Chem. 2007, 50, 1723-1726. 9. Lu, Y.; Wang, R.; Yang, C.-Y.; Wang, S. “Analysis of ligand-bound water molecules in high-resolution crystal structures of protein-ligand complexes”. J. Chem. Inf. Model. 2007, 47, 668-675. 10. Xu, Y.; Wang, R.* “A Computational Analysis of the Binding Affinities of FKBP12 Inhibitors Using the MM-PB/SA Method”, Proteins, 2006, 64, 1058-1068. 11. Yu, S.; Pu, X.; Cheng, T.; Wang, R.; Ma, D. “Total Synthesis of Clavepictines A and B and Pictamine”, Org. Lett. 2006, 8, 3179-3182. 12. Ma, D.; Jiang, Y.; Chen, F.; Gong, L.-k.; Ding, K.; Xu, Y.; Wang, R.; Ge, A.; Ren, J.; Li, J.; Li, J.; Ye, Q. “Selective Inhibition of Matrix Metalloproteinase Isozymes and in Vivo Protection against Emphysema by Substituted -Keto Carboxylic Acids”, J. Med. Chem. 2006, 49, 456-458. 13. Wang, G.; Nikolovska-Coleska, Z.; Yang, C.-Y.; Wang, R.; Tang, G.; Guo, J.; Shangary, S.; Qiu, S.; Gao, W.; Yang, D.; Meagher, J.; Stuckey, J.; Krajewski, K.; Jiang, S.; Roller, P. P.; Abaan, H. O.; Tomita, Y.; Wang, S. “Structure-Based Design of Potent Small-Molecule Inhibitors of Anti-Apoptotic Bcl-2 Proteins”, J. Med. Chem., 2006, 49, 6139-6142. 14. Yang, C.-Y.; Wang, R.; Wang, S. “M-Score: A Knowledge-Based Potential Scoring Function Accounting for Protein Atom Mobility”, J. Med. Chem. 2006, 49, 5903-5911. 15. Wang, R.; Fang, X.; Lu, Y.; Yang, C.-Y.; Wang, S. “The PDBbind Database: Methodologies and Updates”, J. Med. Chem. 2005, 48, 4111-4119. 16. Yang, C.-Y.; Wang, R.; Wang, S. “A Systematic Analysis of the Effect of Small-Molecule Binding on Protein Flexibility of the Ligand-Binding Sites”, J. Med. Chem. 2005, 48, 5648-5650. 17. Song, H.; Wang, R.; Wang, S; Lin, J. “A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells”, Proc. Natl. Acad. Sci. 2005, 102, 4700-4705. 18. Wang R.; Lu Y.; Fang X.; Wang S. “An Extensive Test of 14 Scoring Functions Using the PDBbind Refined Set of 800 Protein-Ligand Complexes”, J. Chem. Inf. Comput. Sci. 2004, 44, 2114-2125. 19. Real P.J.; Cao, Y.; Wang R.; Nikolovska-Coleska Z.; Sanz-Ortiz J.; Wang S.; Fernandez-Luna J. L. “Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2”, Cancer Research, 2004, 64, 7947-7953. 20. Wang, R.; Fang, X.; Lu, Y.; Wang, S. “The PDBbind Database: Collection of Binding Affinities for Protein-Ligand Complexes with Known Three-Dimensional Structures”, J. Med. Chem. 2004, 47, 2977-2980.
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