简介

I. 学习经历:

II. 工作简历:

III. 研究兴趣:

IV. 发表论文:

简介

宋 平, 男, 1969年1月出生。江苏靖江人。2000 年获南京农业大学理学博士学位。现为美国University of Oklahoma Health Sciences Center(OUHSC) 研究助理教授。

I. 学习经历:

1986.09-1990.07 江苏农学院 学士学位

1990.09-1993.06 江苏农学院 硕士学位

1997.09-2000.12 南京农业大学 博士学位

2002.06-2005.05 美国University of Tennessee 博士后

2005.06-2008.08 美国University of Oklahoma Health Sciences Center 博士后

II. 工作简历:

1993.07-2001.05 扬州大学 助教, 讲师

2001.06-2006.08 扬州大学 副教授

2008.09-至今 美国University of Oklahoma Health Sciences Center 研究助理教授

III. 研究兴趣:

Researches in our laboratory are supported by National Institutes of Health (NIH), Scientist Development Grant (SDG) from National Center of American Heart Association (AHA), and Oklahoma Center for the Advancement of Science and Technology (OCAST). These projects involve mouse models of diabetes, aging, and cancer, employ genetic and pharmacologic approaches, with the view of cellular/metabolic reprogramming. The research fields include:

Stem cell differentiation and vascular remodeling。 Genomic instability-related cardiovascular disease。 Cancer and obesity associated angiogenesis。 Endothelial insulin resistance。

IV. 发表论文:

A. Peer-reviewed papers (partial)

1.Song P, and Zou M-H. (2012) Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems. Free Radical Biology and Medicine, 52: 1607-1619

2. Wang S, Song P, and Zou M-H. (2012) AMP-activated protein kinase, stress responses and cardiovascular diseases. Clinical Science, 122: 555-573

3. Wu Y, Zhang C, Dong Y, Wang S, Song P, Viollet B, Zou MH. (2012). Activation of the AMP-activated protein kinase by eicosapentaenoic acid (EPA, 20:5 n-3) improves endothelial function in vivo. PLoS ONE, 7(4):e35508.

4. Wu Y, Dong Y, Song P, Zou M-H. (2012) Activation of the AMP-Activated protein kinase (AMPK) by nitrated lipids in endothelial cells. PLoS ONE 7(2): e31056.

5. Wang S, Song P, and Zou M-H. (2012) Inhibition of AMP-activated protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1.The Journal of Biological Chemistry, 287(11): 8001-8012

6. Song P*, Wang S, He C-Y, Wang S, Liang B, Viollet B, andZou M-H*. (2011) AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells. Circulation Research,109: 1230-1239. (*Corresponding authors)

7.Xu M-J*, Song P*, Shirwany N , Liang B , Xing J , Viollet B , Wang X , Zhu Y , Zou M-H. (2011) Impaired expression of uncoupling protein 2 causes defective postischemic angiogenesis in mice deficient in AMP-activated protein kinase α subunits. Arterioscler Thromb Vasc Biol, 31:1757-1765. (*Joint first authors)

8. Zhang M, Song P, Xu J, Zou M-H. (2011) Activation of NAD(P)H oxidase by thromboxane A2 receptor uncouples endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol,31: 125-132

9. Han Y, Wang Q, Song P, Zhu Y, Zou M-H. (2010) Redox regulation of the AMP-activated protein kinase. PLoS ONE, 5: e15420

10. Wang S, Dale GL, Song P, and Zou M-H. (2010) AMPKα 1 deletion shortens erythrocyte life span in mice: role of oxidative stress. The Journal of Biological Chemistry, 285(26): 19976-19985

11. Xu J, Wang S, Wu Y, Song P, and Zou M-H. (2009) Tyrosine Nitration of PA700 Activates the 26S Proteasome to Induce Endothelial Dysfunction in Mice with Angiotensin II-induced Hypertension. Hypertension, 54: 625-632

12. Dong Y, Wu Y, Wu M, Wang S, Zhang J, Xie Z, Xu J, Song P, Wilson K, Zhao Z, Lyons T, and Zou M-H. (2009) Activation of Protease Calpain by Oxidized and Glycated LDL Increases the Degradation of Endothelial Nitric Oxide Synthase. Journal of Cellular and Molecular Medicine, 13(9a): 2899-2910

13. Wang S, Xu J, Song P, Viollet B, and Zou M-H. (2009) In VivoActivation of AMP-activated Protein Kinase Attenuates Diabetes-enhanced Degradation of GTP Cyclohydrolase I. Diabetes, 58: 1893-1901

14. Song P, Zhang M, Wang S, Xu J, Choi H C, and Zou M-H. (2009) Thromboxane A2 Receptor Activates a Rho-associated Kinase/LKB1/PTEN Pathway to Attenuates Endothelium Insulin Signaling. The Journal of Biological Chemistry, 284(25): 17120-17128

15. Wang S, Xu J, Song P, Wu Y, Zhang J, Choi H C, and Zou M-H. (2008) Acute Inhibition of Guanosine Triphosphate Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure. Hypertension, 52:484-490

16. Choi H C, Song P, Xie Z, Wu Y, Xu J, Zhang M, Dong Y, Wang S, Lau K, and Zou M-H.(2008) Reactive Nitrogen Species Is Required for the Activation of the AMP-activated Protein Kinase by Statin in Vivo. The Journal of Biological Chemistry,283 (29): 20186-20197

17. Song P, Xie Z, Wu Y, Xu J, Dong Y, and Zou M-H. (2008) Protein Kinase C ζ-dependent LKB1 Serine 428 Phosphorylation Increases LKB1 Nucleus Export and Apoptosis in Endothelial Cells. TheJournal of Biological Chemistry, 283(18): 12446-12455

18.Zhang M, Dong Y, Xu J, Xie Z, Wu Y, Song P, Guzman M, Wu J, andZou M-H. (2008) Thromboxane Receptor Activates the AMP-Activated Protein Kinase in Vascular Smooth Muscle Cells via Hydrogen Peroxide. Circulation Research, 102(3): 328-337

19. Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, and Zou M-H. (2007) Reactive Nitrogen Species Induced by Hyperglycemia Suppresses Akt Signaling and Triggers Apoptosis by Upregulating Phosphatase PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) in an LKB1-Dependent Manner. Circulation, 116(14): 1585-1595

20. An Z *, Wang H *, Song P *, Zhang M, Geng X, and Zou M-H. (2007) Nicotine-induced Activation of AMP-activated Protein Kinase Inhibits Fatty Acid Synthase in 3T3L1 Adipocytes: A Role for Oxidant Stress. TheJournal of Biological Chemistry,282(37): 26793-26801. (*Joint first authors)

21. Xu J, Wu Y, Song P, Zhang M, Wang S, and Zou M-H. (2007) Proteasome-dependent Degradation of Guanosine 5’-Triphosphate Cyclohydrolase I Causes Tetrahydrobiopterin Deficiency in Diabetes Mellitus. Circulation, 116(8):944-953

22. Wu Y, Song P, Xu J, Zhang M, and Zou M-H. (2007) Activation of Protein Phosphatase 2A by Palmitate Inhibits AMP-activated Protein Kinase. TheJournal of Biological Chemistry, 282(13): 9777-9788.

23. Song P, Wei J-X, and Wang H-C R. (2005) Distinct roles of the ERK pathway in modulating apoptosis of Ras-transformed and non-transformed cells induced by anticancer agent FR901228. Federation of European Biochemical Societies Letters, 579(1): 90-94

24. Song P, Wei J-X, Plummer III H, and Wang H-C R. (2004) Potentiated caspase-3 in Ras-transformed 10T1/2 cells. Biochemical and Biophysical Research Communications, 322(2):557-564

25. Song P, andWang H-Cn R. (2004) Efficient identification of tetR-expressing cell lines for tetracycline-regulated gene expression. Electronic Journal of Biotechnology,7(2): 210-213

26. Mei J, Hu H, McEntee M, Plummer III H, Song P, and Wang H-C R. (2003) Transformation of non-cancerous human breast epithelial cell line MCF10A by the tobacco-specific carcinogen NNK. Breast Cancer Research and Treatment, 79: 95-105

B. Chapters in Books

宋 平。油菜素甾醇类。《新发现的植物激素》（周燮主编）,江苏科学技术出版社出版2010

宋 平。衰老与脱落。《植物生理学》（王忠主编）农业出版社出版2000

宋 平。植物生长物质习题与答案。《植物生理学-习题与答案》（王忠主编）农业出版社出版2000

宋 平。植物逆境生理习题与答案。《植物生理学-习题与答案》（王忠主编）农业出版社出版2000