中国海洋大学讲师

齐鲁名师、博兴县实验中学教师

中国海洋大学讲师

李红岩，女，讲师，研究方向：发育生物学

目前主要从事教学、科研，为本科生开设《细胞工程》课程。

一、工作经历：

2002-至今 中国海洋大学

期间，2004-2007 Université Pierre et Marie Curie, France 博士后

二、科研方向与项目

目前的科研方向主要有：1）早期发育中基因的功能研究；2）鱼类的免疫与进化

科研项目：

RNA结合蛋白Seb4的表达调控以及在斑马鱼肌肉发生中的功能 国家自然科学基金 主持 2009-2011

RNA结合蛋白在斑马鱼早期发育中的功能研究 教育部留学回国人员基金 主持 2009-2010

鱼类抗感染免疫的分子与细胞基础及其调控 973 参加

IgM的母体传递及其免疫保护作用的机理研究 海洋所开放课题 主持

三、发表论文

1. Bourdelas#, H.Y. Li#, C. Carron and D.L. Shi 2009 Dynamic expression pattern of distinct genes in the presomitic and somitic mesoderm during Xenopus development. Int. J. Dev. Biol. 53: 1075-1079

2. Li HY., Bourdelas A., Carron C., Boucaut J., Gomez C.. Shi DL. 2006, FGF8, Wnt8 and Myf5 are target genes of Tbx6 during anteroposterior specification in Xenopus embryo. Dev. Biol. 290: 470-481.

3. Shao M, Liu ZZ, Wang CD, Li HY, Carron C, Zhang HW, Shi DL. 2009 Down syndrome critical region protein 5 regulates membrane localization of Wnt receptors, Dishevelled stability and convergent extension in vertebrate embryos. Development 136(12):2121-31.

4. Grandy D, Shan J, Zhang X, Rao S, Akunuru S, Li HY, Zhang Y, Alpatov I, Zhang XA, Lang RA, Shi DL, Zheng JJ. 2009 Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. J Biol. Chem. 284(24):16256-63

5. Liu ZH, Li L, Li HY, Zhang SC, Ji GD, Sun YL. 2009 EST analysis of the immune-relevant genes in Chinese amphioxus challenged with lipopolysaccharide. Fish Shellfish Immunol. 26(6):843-9.

6. Bourdelas A., Li HY., Boucaut J., Shi D. Identification of distinct genes with restricted expession in the somitic mesoderm in xenopus embryo. Gene Expression Patterns 2004, 4: 695-699.

7. Liu M., Zhang S., Liu Z., Li H., Xu A. Characterization, organization and expression of AmphiLysC, an acidic c-type lysozyme gene in amphioxus Branchiostoma belcheri tsingtauense. Gene 2006, 367: 110-117.

8. Li H., Zhang vitro cytotoxicity of the organophorous pesticide methylparathion to FG-9307 cells. Cell Biology and Toxicology 2002, 8: 235-241.

9. Li H., Zhang S. In vitro cytotoxicity of the organophorus pesticide parathion to FG-9307 cells. Toxicology in Vitro 2001, 15: 643-647.

10. Carron C., Bourdelas A., Li HY., Boucaut J., Shi DL. Antagonistic interaction between IGF and Wnt/JNK signaling in convergent extension in Xenopus embryo. Mechanisms of Development 2005, 122: 1234-1247.

11. H.Y. Li, S.C. Zhang, M. Wang and M. Jiang, 2001 In vitro study on cytotoxic effects of the organophosphorous pesticide profenofos on the gill cell line, FG-9307, of the flounder (Paralichihys olivaceus) Chinese Journal of Oceanology and Limnology 19(1): 57-62

12. Wang Y, Zhang S, Liu Z, Li H, Wang L. Identification and expression of amphioxus [beta]-microseminoprotein (MSP)-like gene encoding an ancient and rapidly evolving protein in chordates. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2005; 142:251-57.

13. Wang Y, Zhang S, Liu Z, Li H, Wang L. Characterization and expression of AmphiCL encoding cathepsin l proteinase from amphioxus Branchiostoma belcheri tsingtauense. Marine biotechnology 2005; 7:279-86.

14. Luan J, Liu Z, Zhang S, Li H, Fan C, Li L. Characterization, evolution and expression of the calmodulin1 genes from the amphioxus Branchiostoma belcheri tsingtauense. Acta Biochim Biophys Sin (Shanghai). 2007; 39:255-64.

15. Wang Y, Zhang S, Liu Z, Li H, Wang L. Amphioxus allantoicase: molecular cloning, expression and enzymatic activity. Comparative biochemistry and physiology. 2005; 141:237-43.

16. Wang L, Zhang SC, Liang SD, Liu ZH, Li HY, Wang YJ. Characterization and expression of AmphiARF gene encoding a new member of ARF family from amphioxus Branchiostoma belcheri tsingtauense. DNA Sequence - The Journal of Sequencing and Mapping. 2005; 16:418-25.

17. Liu Z, Zhang S, Li H, et al. Characterization and expression profile of AmphiCD63 encoding a novel member of TM4SF proteins from amphioxus Branchiostoma belcheri tsingtauense. DNA Seq. 2005; 16:195-201.

18. Li X, Zhang S, Liu Z, Li H. Ribosomal Protein Genes S23 and L35 from Amphioxus Branchiostoma belcheri tsingtauense: Identification and Copy Number. Acta Biochimica et Biophysica Sinica. 2005; 37: 573-79.

19. Wang L, Zhang S, Liu Z, Li H, Wang Y, Jiang S. 2007 Characterization and expression of amphioxus ApoD gene encoding an archetype of vertebrate ApoD proteins. Cell Biol Int. 31:74-81.

20. G. S.C. Zhang and H.Y. Li, 2001 Ultrastructural localization and antibacterial activity of phenoloxidase in amphioxus Branchiostoma belcheri tsingtauense. Journal of the Marine Biological Association of the United Kingdom 81: 705-706

21. S.C. Zhang, L. Li, and H.Y. Li, 2002 Histochemical localization of constitutive nitric oxide synthases in amphioxus Branchiostoma belcheri tsingtauense. Journal of the Marine Biological Association of the United Kingdom 82: 1041-1042

22. H.R. Guo, S.C. Zhang, and H.Y. Li, 2003 Spontaneous neoplastic transformation of the cell line FG-9307 of the flounder (Paralichthys olivaceus) North American Journal of Aquaculture 65: 44-48

23. H.R. Guo, S.C. Zhang and H.Y. Li, 2002 Characterization of lactate dehydrogenase isozyme pattern and morphology of three marine fish cell lines of FG, SPH and RSBF. Chinese Journal of Oceanology and Limnology 20(3): 246-251

24. L. Li, S.C. Zhang, J.D.Yuan and H.Y. Li, 2003 Development of inter-family nulear transplant embryos by transplanting the the nuclei from the loach blastulae into the non-enucleated zebrafish eggs. Chinese Journal of Oceanology and Limnology 21(1): 64-71

四、奖励

1. 国家海洋局科技进步一等奖，第三位，2003年

2. 教育部自然科学二等奖，第四位，2006年

齐鲁名师、博兴县实验中学教师

李红岩，博兴县实验中学英语教师，本科，中国共产党员，中学高级教师；曾获山东省优质课一等奖，多次执教省、市、县公开课；滨州市英语教学能手、学科带头人；山东省骨干教师；滨州市创新教师；滨州市第四届名师；全国优秀教师；第五届全国中小学英语教师园丁奖；，辅导的学生多次获全国中学生能力大赛一、二等奖；辅导10余位青年教师获国家、省、市优质课奖；曾赴澳大利亚墨尔本霍姆斯学院参加英语培训；所写的多篇论文发表在中国教育报、学英语报等；承担的全国教育科学“十一五”规划教育部课题《七步整体教学法在阅读与写作教学中的应用》，通过验收并结题；连续九年获学校首席名师称号。